1-(1-methylethyl)piperidine-4-carboxylic acid

1-(1-methylethyl)piperidine-4-carboxylic acid - Names and Identifiers

Name	1-(1-methylethyl)piperidine-4-carboxylic acid
Synonyms	1-isopropylpiperidine-4-carboxylic acid 1-isopropyl-4-piperidin-1-iumcarboxylate 1-isopropylpiperidin-1-ium-4-carboxylate 1-propan-2-yl-4-piperidinecarboxylic acid 1-(propan-2-yl)piperidine-4-carboxylic acid 1-isopropylpiperidine-4-carboxylic acid 1HCl 1-(1-Methylethyl)-4-piperidinecarboxylic acid 1-(1-methylethyl)piperidine-4-carboxylic acid 4-Piperidinecarboxylicacid, 1-(1-Methylethyl)- 4-Piperidinecarboxylicacid,1-(1-methylethyl)-(9CI)
CAS	280771-97-3
InChI	InChI=1/C9H17NO2/c1-7(2)10-5-3-8(4-6-10)9(11)12/h7-8H,3-6H2,1-2H3,(H,11,12)

1-(1-methylethyl)piperidine-4-carboxylic acid - Physico-chemical Properties

Molecular Formula	C9H17NO2
Molar Mass	171.24
Density	1.057
Boling Point	272℃
Flash Point	118℃
Vapor Presure	0.00179mmHg at 25°C
pKa	4.04±0.20(Predicted)
Storage Condition	Room Temprature
Refractive Index	1.487

1-(1-methylethyl)piperidine-4-carboxylic acid - Risk and Safety

Hazard Class

IRRITANT

1-(1-methylethyl)piperidine-4-carboxylic acid - Introduction

1-(1-methyllethyl) piperidine-4-carboxylic acid, also known as 1-(1-methyllethyl) piperidine-4-carboxylic acid, is an organic compound whose chemical structure contains a piperidine ring and a carboxylic acid group.

The properties and uses of this compound are as follows:
1. Properties: 1-(1-methyllethyl) piperidine-4-carboxylic acid is a white crystalline solid, soluble in some organic solvents such as chloroform and methanol. It can form salts and Ester derivatives.
2. Uses: 1-(1-methyllethyl) piperidine-4-carboxylic acid is commonly used as a reagent and intermediate in organic synthesis, especially for the preparation of drugs and pesticides. It can also be used to prepare liquid crystal monomers, pigments and dyes.

The method of preparing 1-(1-methyllethyl) piperidine-4-carboxylic acid usually includes the following steps:
1. Synthesis of piperidine ring: 4-piperidone (4-piperidone) is synthesized first, and then it is converted into piperidine ring by hydrogenation reduction or amination reaction.
2. Isopropylation: replacing a hydrogen atom in the piperidine ring with an isopropyl group can be achieved by alkyl halogenation. The commonly used alkyl halogenation agent is methyl iodide.
3. Carboxylation: Finally, the carboxylic acid group is introduced by the carboxylic acid reaction. Commonly used carboxylic acid reagents include carbonyl chloride and trichloromethane sulfonyl chloride.

Regarding safety information, 1-(1-methyllethyl) piperidine-4-carboxylic acid is a chemical substance. The following should be paid attention to during storage and use:
1. Avoid contact with skin and eyes, such as accidental contact, should immediately rinse with plenty of water and seek medical help.
2. Wear appropriate personal protective equipment such as lab gloves and goggles when in use.
3. Avoid inhaling its vapor or dust, and operate in a well-ventilated place.
4. Storage, should be kept in a dry, cool place, and away from combustibles and oxidants.

It should be noted that the above information is for reference only. For specific safe operation and use, please refer to the relevant safety data sheet and user guide.

Last Update：2024-04-09 21:00:56